Background and Aims- A fracture and retention of guidewire after cardiac resynchronization therapy device implant has not been reported so far, although it is an uncommon but known complication during cardiac interventions like percutaneous coronary interventions and other cardiac catheterization procedures. Methods- A 53 years old female patient presented to us, who had been diagnosed as a case of dilated cardiomyopathy with severe left ventricular dysfunction and underwent cardiac resynchronization therapy (CRT-D) device implant three years back and subsequently underwent lead replacement 6 months back due to lead dysfunction, with severe pain over the left arm and shoulder for last 1-2 days. On evaluation, it was found that she had a coronary guidewire which might have fractured and retained inadvertently in previous surgical procedure and has caused her symptoms that might have been aggravated by the movements of her arm. Emergency surgical exploration was done and the guidewire which was impacted in deltoid muscle was removed. Results, and Conclusion- We are reporting the case due to a very unlikely and unusual delayed presentation of retained intervention guide-wire post cardiac resynchronization therapy, retrieved from left deltoid muscle.