Role of Dietary Fiber in Promoting Immune Health -- An EAACI Position
Paper
- Carina Venter,
- Rosan Meyer,
- Matthew Greenhawt,
- Isabella Pali-Schöll,
- Bright Nwaru,
- Caroline Roduit,
- Eva Untersmayr,
- K Adel-Patient,
- Ioana Agache,
- Carlo Agostoni,
- Cezmi Akdis,
- Mary Feeney,
- Karin Hoffmann-Sommergruber,
- Nonhlanhla Lunjani,
- Kate Grimshaw,
- Imke Reese,
- Pete Smith,
- Milena Sokolowska,
- Emilia Vassilopoulou,
- Berber Vlieg - Boerstra,
- Jens Walter,
- Liam O'Mahony
Carina Venter
Section of Allergy and Immunology University of Colorado School of Medicine
Corresponding Author:carina.venter@childrenscolorado.org
Author ProfileMatthew Greenhawt
Section of Allergy and Immunology University of Colorado School of Medicine
Author ProfileIsabella Pali-Schöll
Comparative Medicine Messerli Research Institute of the University of Veterinary Medicine Vienna Medical University Vienna Vienna Austria
Author ProfileBright Nwaru
Goteborgs universitet Institutionen for medicin
Author ProfileEva Untersmayr
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author ProfileK Adel-Patient
Université Paris-Saclay CEA INRAE UMR MTS/SPI/Laboratoire d'Immuno-Allergie Alimentaire (LIAA) INRA CEA Université Paris Saclay Gif sur Yvette Cedex France
Author ProfileCarlo Agostoni
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Author ProfileCezmi Akdis
Christine Kühne-Center for Allergy Research and Education Davos Switzerland
Author ProfileMary Feeney
King's College London Division of Asthma Allergy and Lung Biology
Author ProfileKarin Hoffmann-Sommergruber
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
Author ProfileNonhlanhla Lunjani
University College Cork APC Microbiome Institute
Author ProfileImke Reese
Private Practice for Dietary Advice and Nutrition Therapy Munich Germany
Author ProfilePete Smith
Griffith University School of Medicine and Dentistry
Author ProfileMilena Sokolowska
Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland
Author ProfileEmilia Vassilopoulou
Department of Nutritonal Sciences and Dietetics International Hellenic University Thessaloniki Greece
Author ProfileBerber Vlieg - Boerstra
OLVG Department of Paediatrics Amsterdam The Netherlands
Author ProfileJens Walter
University College Cork APC Microbiome Institute
Author ProfileLiam O'Mahony
University College Cork APC Microbiome Institute
Author ProfileAbstract
Microbial metabolism of specific dietary components, such as fiber,
contribute to the sophisticated inter-kingdom dialogue in the gut that
maintains a stable environment with important beneficial physiological,
metabolic, and immunological effects on the host. Historical changes in
fiber intake may be contributing to the increase of allergic and
hypersensitivity disorders as fiber-derived metabolites are
evolutionarily hardwired into the molecular circuitry governing immune
cell decision making processes. In this review, we highlight the
importance of fiber as a dietary ingredient, its effects on the
microbiome, its effects on immune regulation, and potential mechanisms
for dietary fibers in the prevention and management of allergic
diseases. In addition, we review the human studies examining fiber or
prebiotic interventions on asthma and respiratory outcomes, allergic
rhinitis, atopic dermatitis, and overall risk of atopic disorders. While
exposures, interventions and outcomes were too heterogeneous for
meta-analysis, there is significant potential for using fiber in
targeted manipulations of the gut microbiome and its metabolic functions
in promoting immune health.19 Nov 2021Submitted to Allergy 23 Nov 2021Submission Checks Completed
23 Nov 2021Assigned to Editor
28 Nov 2021Reviewer(s) Assigned
29 Dec 2021Review(s) Completed, Editorial Evaluation Pending
04 Jan 2022Editorial Decision: Revise Minor
19 Apr 20221st Revision Received
20 Apr 2022Submission Checks Completed
20 Apr 2022Assigned to Editor
20 Apr 2022Reviewer(s) Assigned
03 May 2022Review(s) Completed, Editorial Evaluation Pending
07 May 2022Editorial Decision: Revise Minor
27 Jun 20222nd Revision Received
28 Jun 2022Submission Checks Completed
28 Jun 2022Assigned to Editor
28 Jun 2022Reviewer(s) Assigned
29 Jun 2022Review(s) Completed, Editorial Evaluation Pending
05 Jul 2022Editorial Decision: Accept