Figure
Summary receiver operator characteristic curves (SROC) from all 22
papers including results on two assay types from six of the paper, so 28
results in total. Note we have only presented SROC curves as different
stimulation index (SI) thresholds for a positive value were used across
all studies. A - studies immediately analyzing whole blood with flow
cytometry, n=17, I2=59.78% (95% CI 30.3 – 76.7%),
tau20.292; B – studies measuring sulfidoleukotriene
release, n=4, I2=26.9% (95% CI 0 – 72.5%),
tau2 0.0; C – studies measuring histamine release ,
n=2, I2=15.8%, tau20; D studies
using a direct method of observing basophils, n=2,
I2=91.8% (95% CI71.7% - 97.6%),
tau23.3713; D studies using an indirect method of
observing basophils, n=2, I2=0%,
tau20 .