Objective: To discuss the effect of improved method in otomycosis with pevisone. Method: 160 patients of otomycosis were randomly divided into traditional group (TG) and improved group (IG) equally. All the patients，external auditory canals (EACs) were cleaned by the cerumen hook and attractor, in TG, pevisone was applied by traditional method after cleaning the EACs, but in IG, the cotton balls were used to clean the EACs additionally and pevisone was applied by our improved method. The treatment was implemented once every other day for three times in total in two groups. At 3d, 1wk, 1mo, 6mo of treatment, cure rates were analyzed and compared between the two groups,at 6mo of treatment the recurrence rate was compared between the two groups. Results: The cure rates in the IG(50%,66.7%,61.5%,53.8%) were higher than that in the TG(32.9%,48.7%,46.1%,34.2%) at four observation time points respectively,the difference between the two groups were statistically significant(p<0.05).The recurrence rate in IG was lower than which in TG(9%vs22.4%)at 6mo of treatment(p<0.05). Conclusion: The effect of improved method in otomycosis with pevisone has great advantages both in the therapeutic effect and treating process, which is worth further promoting in clinical practice.