Pharmacodynamics
Reduction of serum glucose level during OGTT for EVO+PIO was greater than PIO and similar to EVO (Figure 3). The Gmax,ss and AUGCτ,ss for EVO+PIO compared to baseline also showed similar trend (Table 3). On the other hand, reduction of plasma insulin level during OGTT for all treatments were similar (Figure 3), as well as the Emax,ss and AUECτ,ss (Table 3).