Pharmacodynamics
Reduction of serum glucose level during OGTT for EVO+PIO was greater
than PIO and similar to EVO (Figure 3). The Gmax,ss and
AUGCτ,ss for EVO+PIO compared to baseline also showed
similar trend (Table 3). On the other hand, reduction of plasma insulin
level during OGTT for all treatments were similar (Figure 3), as well as
the Emax,ss and AUECτ,ss (Table 3).