Statistical analysis
Descriptive statistics were used to summarized demographic
characteristics, pharmacokinetic and pharmacodynamic parameters. To
assess pharmacokinetic interaction between evogliptin and pioglitazone,
geometric mean ratios (GMR) and 90% confidence intervals (CI) of
log-transformed pharmacokinetic parameters (Cmax,ss,
AUCτ,ss) of EVO+PIO and EVO or PIO alone were calculated
using linear mixed effect model which assumed treatment, period and
sequence as fixed effect.