Statistical analysis
Descriptive statistics were used to summarized demographic characteristics, pharmacokinetic and pharmacodynamic parameters. To assess pharmacokinetic interaction between evogliptin and pioglitazone, geometric mean ratios (GMR) and 90% confidence intervals (CI) of log-transformed pharmacokinetic parameters (Cmax,ss, AUCτ,ss) of EVO+PIO and EVO or PIO alone were calculated using linear mixed effect model which assumed treatment, period and sequence as fixed effect.