Safety/tolerability evaluations
Safety/tolerability evaluations including adverse events (AEs), physical examinations, clinical laboratory tests, vital sign measurements, and ECG were conducted In addition, ophthalmic examinations including best corrected visual acuity, intraocular pressure, refractive error, slit-lamp examination, fundus examination, tear break-up time test, Schirmer’s test, and ocular surface disease index (OSDI) were conducted.