Outcomes and Sub-analysis
Patients were stratified into low and high-risk cohorts based on the peak preoperative troponin level, with the threshold for stratification centered around the median troponin level for the study cohort. The primary outcome of this study was long-term major adverse cardiac and cerebrovascular events (MACCE), which is a composite of death, myocardial infarction, stroke, or need for repeat revascularization procedures. Other outcomes investigated included short and long-term survival, postoperative complications, and intensive care unit and hospital length of stay. Predictors of MACCE and mortality were also modeled.
Preoperative peak troponin levels were also evaluated when modeled as a continuous variable. A secondary sub-analysis was performed with a clinically meaningful troponin threshold of 10.00 ng/mL to define high- and low-risk cohorts as well. In this secondary analysis, long-term MACCE and survival were analyzed and modeled using multivariable analysis.