\documentclass[10pt]{article}

\usepackage{fullpage}
\usepackage{setspace}
\usepackage{parskip}
\usepackage{titlesec}
\usepackage[section]{placeins}
\usepackage{xcolor}
\usepackage{breakcites}
\usepackage{lineno}
\usepackage{hyphenat}





\PassOptionsToPackage{hyphens}{url}
\usepackage[colorlinks = true,
            linkcolor = blue,
            urlcolor  = blue,
            citecolor = blue,
            anchorcolor = blue]{hyperref}
\usepackage{etoolbox}
\makeatletter
\patchcmd\@combinedblfloats{\box\@outputbox}{\unvbox\@outputbox}{}{%
  \errmessage{\noexpand\@combinedblfloats could not be patched}%
}%
\makeatother


\usepackage{natbib}




\renewenvironment{abstract}
  {{\bfseries\noindent{\abstractname}\par\nobreak}\footnotesize}
  {\bigskip}

\titlespacing{\section}{0pt}{*3}{*1}
\titlespacing{\subsection}{0pt}{*2}{*0.5}
\titlespacing{\subsubsection}{0pt}{*1.5}{0pt}


\usepackage{authblk}


\usepackage{graphicx}
\usepackage[space]{grffile}
\usepackage{latexsym}
\usepackage{textcomp}
\usepackage{longtable}
\usepackage{tabulary}
\usepackage{booktabs,array,multirow}
\usepackage{amsfonts,amsmath,amssymb}
\providecommand\citet{\cite}
\providecommand\citep{\cite}
\providecommand\citealt{\cite}
% You can conditionalize code for latexml or normal latex using this.
\newif\iflatexml\latexmlfalse
\providecommand{\tightlist}{\setlength{\itemsep}{0pt}\setlength{\parskip}{0pt}}%

\AtBeginDocument{\DeclareGraphicsExtensions{.pdf,.PDF,.eps,.EPS,.png,.PNG,.tif,.TIF,.jpg,.JPG,.jpeg,.JPEG}}

\usepackage[utf8]{inputenc}
\usepackage[ngerman,english]{babel}



\usepackage{float}








\begin{document}

\title{Vaccines and Allergic reactions: the past, the current COVID-19
pandemic, and future perspectives}



\author[1]{Vanitha Sampath}%
\author[2]{Grace Rabinowitz}%
\author[1]{Mihir Shah}%
\author[2]{Surabhi Jain}%
\author[3]{Zuzana Diamant}%
\author[4]{Milos Jesenak}%
\author[5]{Ronald Rabin}%
\author[6]{Stefan Vieths}%
\author[7]{Ioana Agache}%
\author[8]{Domingo Barber Hernández}%
\author[9]{Sharon Chinthrajah}%
\author[10]{T. Chivato}%
\author[2]{William Collins}%
\author[11]{Thomas Eiwegger}%
\author[1]{Katie Fast}%
\author[12]{Wytske Fokkens}%
\author[13]{Robyn O'Hehir}%
\author[14]{Markus Ollert}%
\author[15]{Liam O'Mahony}%
\author[16]{Oscar Palomares}%
\author[17]{Oliver Pfaar}%
\author[18]{CARMEN RIGGIONI}%
\author[19]{Mohamed Shamji}%
\author[20]{ Milena Sokolowska}%
\author[21]{Claudia Traidl-Hoffmann}%
\author[22]{De Yun Wang}%
\author[23]{Menno van Zelm}%
\author[24]{Luo Zhang}%
\author[25]{Cezmi Akdis}%
\author[2]{Kari Nadeau}%
\author[26]{María José Torres}%
\affil[1]{Stanford University School of Medicine}%
\affil[2]{Stanford University}%
\affil[3]{Skåne University Hospital Labmedicin Skane}%
\affil[4]{Jessenius School of Medicine, Comenius University in Bratislava}%
\affil[5]{Food and Drug Administration Office of Global Regulatory Operations and Policy}%
\affil[6]{Paul-Ehrlich-Institut, }%
\affil[7]{Transylvania University of Brasov}%
\affil[8]{Universidad San Pablo CEU}%
\affil[9]{Stanford Hospital and Clinics}%
\affil[10]{Univ CEU San Pablo}%
\affil[11]{The Hospital for Sick Children}%
\affil[12]{Academic Medical Centre}%
\affil[13]{Alfred Hospital}%
\affil[14]{Luxembourg Institute of Health}%
\affil[15]{University College Cork National University of Ireland}%
\affil[16]{Complutense University of Madrid}%
\affil[17]{ University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.}%
\affil[18]{Hospital Sant Joan de Déu}%
\affil[19]{Imperial College London}%
\affil[20]{University of Zurich Faculty of Medicine}%
\affil[21]{Institute of Environmental Medicine, UNIKA-T}%
\affil[22]{Yong Loo Lin School of Medicine, National University of Singapore}%
\affil[23]{Monash University}%
\affil[24]{Beijing TongRen Hospital, Capital Medical University, }%
\affil[25]{University of Zurich}%
\affil[26]{Universidad de Málaga Facultad de Medicina}%


\vspace{-1em}



  
  \date{May 03, 2024}


\begingroup
\let\center\flushleft
\let\endcenter\endflushleft
\maketitle
\endgroup





\selectlanguage{english}
\begin{abstract}
Vaccines are essential public health tools with a favorable safety
profile and prophylactic effectiveness that have historically played
significant roles in reducing infectious disease burden in populations,
when the majority of individuals are vaccinated. The COVID-19 vaccines
are expected to have similar positive impacts on health across the
globe. While serious allergic reactions to vaccines are rare, their
underlying mechanisms and implications for clinical management should be
considered to provide individuals with the safest care possible. In this
review, we provide an overview of different types of allergic adverse
reactions that can potentially occur after vaccination and individual
vaccine components capable of causing the allergic adverse reactions. We
present the incidence of allergic adverse reactions during clinical
studies and through post-authorization and post-marketing surveillance
and provide plausible causes of these reactions based on potential
allergenic components present in several common vaccines. Additionally,
we review implications for individual diagnosis and management and
vaccine manufacturing overall. Finally, we suggest areas for future
research.%
\end{abstract}%



\sloppy


\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-1/Figure-1}

\end{center}
\end{figure}\selectlanguage{english}
\begin{figure}[H]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Figure-2/Figure-2}

\end{center}
\end{figure}

\selectlanguage{english}
\FloatBarrier
\end{document}

