loading page

Value of pretreatment prognostic nutritional index in predicting intravenous immunoglobin-resistant Kawasaki disease
  • +7
  • Gang Li,
  • Xiumei Xu,
  • Pengyuan Chen,
  • Yongying Gou,
  • Rumeng Zeng,
  • Dong Liu,
  • Yan Duan,
  • Ting Wang,
  • Peng Jia,
  • Bin Liu
Gang Li
The Affiliated Hospital of Southwest Medical University

Corresponding Author:479719170@qq.com

Author Profile
Xiumei Xu
The Affiliated Hospital of Southwest Medical University
Author Profile
Pengyuan Chen
Sichuan Academy of Medical Sciences and Sichuan People's Hospital
Author Profile
Yongying Gou
The Affiliated Hospital of Southwest Medical University
Author Profile
Rumeng Zeng
The Affiliated Hospital of Southwest Medical University
Author Profile
Dong Liu
The Affiliated Hospital of Southwest Medical University
Author Profile
Yan Duan
The Affiliated Hospital of Southwest Medical University
Author Profile
Ting Wang
The Affiliated Hospital of Southwest Medical University
Author Profile
Peng Jia
The Affiliated Hospital of Southwest Medical University
Author Profile
Bin Liu
The Affiliated Hospital of Southwest Medical University
Author Profile

Abstract

Background: The aim of the present study was to investigate the potential predictive significance of pretreatment prognostic nutritional index (PNI) in patients with intravenous immunoglobulin (IVIG) resistant Kawasaki disease (KD). Methods: From June 2013 to May 2020, 1,257 eligible patients with KD were included in the present study. The pretreatment PNI was calculated as albumin level (g/L) +5×total lymphocyte count (109/L). The optimal cut-off values for PNI, neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) were evaluated via a receiver operating curve analysis. The impact of pretreatment PNI, NLR and PLR for IVIG resistant KD were tested with the Student’s t test or Mann-Whitney U test, and univariate and multivariate analyses. Results: The optimal cut-off values were identified as 49.50 for PNI, 3.58 for NLR and 164.00 for PLR, respectively. Lower pretreatment PNI levels were demonstrated to be associated with lower age, serum sodium levels and platelet counts, and with a higher incidence of IVIG resistance and higher C-reactive protein levels. There was a significantly negative association between the PNI and NLR, and PLR. In the logistic analyses, PNI as independent predictive factors were significantly correlated with IVIG resistance. The discriminatory ability of PNI was not inferior to NLR and PLR for predicting IVIG resistance. Conclusion: Pretreatment PNI could serve as a novel surrogate independent predictor for patients with IVIG resistant KD.