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COVID-19-vaccination in patients receiving allergen immunotherapy (AIT) or biologics - EAACI recommendations
  • +66
  • Marek Jutel,
  • María José Torres,
  • Oscar Palomares,
  • Cezmi Akdis,
  • Thomas Eiwegger,
  • Eva Untersmayr,
  • Domingo Barber Hernández,
  • Magdalena Zemelka-Wiacek,
  • Anna Kosowska,
  • Elizabeth Palmer,
  • Stefan Vieths,
  • Vera Mahler,
  • Giorgio Walter Canonica,
  • Kari Nadeau,
  • Mohamed Shamji,
  • Ioana Agache,
  • Mubeccel Akdis,
  • Musa Khaitov,
  • Alberto Alvarez-Perea,
  • Montserrat Alvaro,
  • Marina Atanasković-Marković,
  • Vibeke Backer,
  • Annick BARBAUD,
  • Sevim Bavbek,
  • Frédéric De Blay,
  • Matteo Bonini,
  • Sergio Bonini,
  • Job van Boven,
  • Knut Brockow,
  • Mario Cazzola,
  • Alexia Chatzipetrou,
  • T. Chivato,
  • A. Cianferoni,
  • Jonathan Corren,
  • Jean-Christoph Caubet,
  • Audrey DunnGalvin,
  • Motohiro Ebisawa,
  • Davide Firinu,
  • Radoslaw Gawlik,
  • Asli Gelincik,
  • Stefano Del Giacco,
  • Charlotte Mortz,
  • H.J. Hoffmann,
  • Karin Hoffmann-Sommergruber,
  • Ludger Klimek,
  • Antti Lauerma,
  • Luis Perez de Llano,
  • Andrea Matucci,
  • Rosan Meyer,
  • André Moreira,
  • Hideaki Morita,
  • Sarita Patil,
  • Oliver Pfaar,
  • Florin-Dan Popescu,
  • VICTORIA DEL POZO,
  • Oliver Price,
  • Ronald van Ree,
  • Montserrat Fernandez-Rivas,
  • Barbara Rogala,
  • Antonino Romano,
  • Alexandra Santos,
  • Anna Sediva,
  • Isabel Skypala,
  • Sylwia Smolinska,
  • Milena Sokolowska,
  • Gunter Sturm,
  • Alessandra Vultaggio,
  • Jolanta Walusiak-Skorupa,
  • Margitta Worm
Marek Jutel
Wroclaw Medical University

Corresponding Author:marek.jutel@umed.wroc.pl

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María José Torres
Universidad de Málaga Facultad de Medicina
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Oscar Palomares
Complutense University of Madrid
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Cezmi Akdis
University of Zurich
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Thomas Eiwegger
The Hospital for Sick Children
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Eva Untersmayr
Center of Physiology, Pathophysiology and Immunology
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Domingo Barber Hernández
Universidad San Pablo CEU
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Magdalena Zemelka-Wiacek
University of Wroclaw
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Anna Kosowska
Wroclaw Medical University
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Elizabeth Palmer
Imperial College London
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Stefan Vieths
Paul-Ehrlich-Institut,
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Vera Mahler
Paul-Ehrlich-Institut
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Giorgio Walter Canonica
Humanitas University Head Personalized Medicine Asthma & Allergy Clinic-Humanitas Research Hospital-IRCCS, Milano, Italy
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Kari Nadeau
Stanford University
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Mohamed Shamji
Imperial College London
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Ioana Agache
Transylvania University of Brasov
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Mubeccel Akdis
University of Zürich
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Musa Khaitov
NRC Institute of Immunology
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Alberto Alvarez-Perea
Hospital General Universitario Gregorio Marañón
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Montserrat Alvaro
Hospital Sant Joan de Deu
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Marina Atanasković-Marković
University of Belgrade, Facuty of Medicine
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Vibeke Backer
Bispebjerg University Hospital
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Annick BARBAUD
Sorbonne Universités, UPMC Univ Paris 06
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Sevim Bavbek
Ankara University Faculty of Medicine
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Frédéric De Blay
University Hospital Strasbourg
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Matteo Bonini
Imperial College London Faculty of Medicine
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Sergio Bonini
National Research Council
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Job van Boven
Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Knut Brockow
Technical University of Munich
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Mario Cazzola
University of Rome Tor Vergata
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Alexia Chatzipetrou
National University of Athens, Medical School
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T. Chivato
Univ CEU San Pablo
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A. Cianferoni
the childrens' Hospital of Philadelphia
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Jonathan Corren
University of California, Los Angeles
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Jean-Christoph Caubet
Univ Hosp Geneva
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Audrey DunnGalvin
University College Cork (UCC)
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Motohiro Ebisawa
Sagamihara National Hospital
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Davide Firinu
University of Cagliari
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Radoslaw Gawlik
Medical University of Silesia
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Asli Gelincik
Istanbul University
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Stefano Del Giacco
University of Cagliari
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Charlotte Mortz
Odense Universityhospital
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H.J. Hoffmann
European Academy of Allergy and Clinical Immunology; Department of Clinical Medicine, Aarhus University
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Karin Hoffmann-Sommergruber
Medical University Vienna
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Ludger Klimek
Center for Rhinology and Allergology Wiesbaden
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Antti Lauerma
University of Helsinki
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Luis Perez de Llano
Hospital Universitario Lucus Augusti
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Andrea Matucci
Azienda Ospedaliero-Universitaria Careggi
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Rosan Meyer
Imperial College
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André Moreira
Faculty of Medicine
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Hideaki Morita
National Research Institute for Child Health and Development
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Sarita Patil
Massachusetts General Hospital and Harvard Medical School
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Oliver Pfaar
University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
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Florin-Dan Popescu
Universitatea de Medicina si Farmacie Carol Davila
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VICTORIA DEL POZO
Fundación Jiménez Díaz
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Oliver Price
University of Leeds
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Ronald van Ree
Academic Medical Center
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Montserrat Fernandez-Rivas
Hospital Clinico San Carlos
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Barbara Rogala
Medical University of Silesia
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Antonino Romano
Allergy Unit Complesso Integrato Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy
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Alexandra Santos
King's College London Faculty of Life Sciences and Medicine
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Anna Sediva
Motol University Hospital Department of Cardiology 2nd Faculty of Medicine
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Isabel Skypala
Royal Brompton & Harefield
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Sylwia Smolinska
Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu
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Milena Sokolowska
Swiss Institute of Allergy and Asthma Research, University of Zurich
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Gunter Sturm
Medizinische Universitat Graz
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Alessandra Vultaggio
University Hospital Careggi
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Jolanta Walusiak-Skorupa
Nofer Institute of Occupational Medicine
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Margitta Worm
Charité - Universitätsmedizin Berlin
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Abstract

Immune modulation is a key therapeutic tool for allergic diseases and asthma. It can be achieved in an antigen-specific way via allergen immunotherapy (AIT) or in endotype-driven approach using biologicals that target the major pathways of the type 2 (T2) immune response: IgE, IL-5 and IL-4/IL-13. COVID-19 vaccine provides an excellent opportunity to tackle the global pandemics and is currently being applied in an accelerated rhythm worldwide. It works as well through immune modulation. Thus, as there is an obvious interference between these treatment modalities recommendations on how they should be applied in sequence are expected. The European Academy of Allergy and Clinical Immunology (EAACI) gathered an outstanding expert panel under its Research and Outreach Committee (ROC). This expert panel was called to evaluate the evidence and formulate recommendation on the administration of COVID-19 vaccine in patients with allergic diseases and asthma receiving AIT or biologicals. The panel also formulated recommendations for COVID-19 vaccine in association with biologicals targeting the type 1 or type 3 immune response. In formulating recommendations, the panel evaluated the mechanisms of COVID-19 infection, of COVID-19 vaccine, of AIT and of biologicals and considered the data published for other anti-infectious vaccines administered concurrently with AIT or biologicals.
09 Jun 2021Submitted to Allergy
18 Jun 2021Submission Checks Completed
18 Jun 2021Assigned to Editor
24 Jun 2021Reviewer(s) Assigned
08 Jul 2021Review(s) Completed, Editorial Evaluation Pending
09 Jul 2021Editorial Decision: Revise Minor