Is the generation of mutated and more pathogenic strains of SARS-CoV-2 expected?
There are 2 strains of SARS-CoV-2 that are clinically relevant. Genome analysis of SARS-CoV-2 from human samples shows high rates of mutation and deletion in several viral genes, including the spike-glycoprotein gene.25 COVID-19 treatments, including future vaccination against SARS-CoV-2, may drive the genetic evolution of the virus affecting virulence and pathogenicity. For example, a report on a 382-nt deletion in ORF8 of SARS-CoV2 isolated from patients in Singapore implied that mutations may arise as a result of human adaptation and could be associated with attenuation.26 Nevertheless, the emergence of a SARS-CoV-3 is possible as long as there is close contact between humans and living animals that harbor coronaviruses.