Of the drugs being assessed for COVID-19 treatment, which
ones are more immunogenic or associated with hypersensitivity
reactions?
Immunomodulatory drugs (including azithromycin),
hydroxychloroquine/chloroquine and IFNs, are the ones most frequently
involved in hypersensitivity reactions. Most reactions are non-immediate
and further studies are required to clarify whether this increased
frequency is caused by the drug immunogenicity or simply derives from a
greater consumption as compared to other
treatments.146