Are primary immunodeficiency patients at increased risk to
develop severe COVID-19?
Primary immunodeficient patients are a high-risk group in the current
pandemic, but to date it is unknown if a particular immunodeficiency
poses a higher risk of severe disease. International primary
immunodeficiency monitoring is being carried out and few cases have been
documented. Patients at higher risk are those with complications
resulting from their primary immunodeficiency and strict follow-up must
be done in those cases. A consensus has been established that baseline
chronic treatment should be continued in those patients if they are
asymptomatic or mildly symptomatic. Furthermore, recommendations
regarding primary immunodeficient patients adhere to individual national
guidelines emphasizing social distancing and strict hygiene measures.
Systematic testing of primary immunodeficient patients is not advised,
however recommendations may change as the pandemic
evolves.75