Are primary immunodeficiency patients at increased risk to develop severe COVID-19?
Primary immunodeficient patients are a high-risk group in the current pandemic, but to date it is unknown if a particular immunodeficiency poses a higher risk of severe disease. International primary immunodeficiency monitoring is being carried out and few cases have been documented. Patients at higher risk are those with complications resulting from their primary immunodeficiency and strict follow-up must be done in those cases. A consensus has been established that baseline chronic treatment should be continued in those patients if they are asymptomatic or mildly symptomatic. Furthermore, recommendations regarding primary immunodeficient patients adhere to individual national guidelines emphasizing social distancing and strict hygiene measures. Systematic testing of primary immunodeficient patients is not advised, however recommendations may change as the pandemic evolves.75