Statistical analysis
Data analyses were conducted using SPSS version 26. Differences in mean scores from the study sample and published norm mean scores for the WHOQoL BREF21, the PSS23 and the HADS24 were analysed using one-sample t-tests. Differences across categorical variables and across different anaphylaxis trigger groups were analysed using t-tests and one-way ANOVAs. When analysing across different trigger groups, participants with anaphylaxis to more than one cause (n=2) were excluded to ensure they were not counted more than once in the analysis. Relationships between QoL, anxiety, depression, stress and continuous demographic and clinical variables were analysed using Pearson’s correlations. Variables significantly associated with anaphylaxis related QoL (as measured by the A-QoL-Adults) were entered into a regression model to explore significant predictors of QoL in adults. All tests were two-tailed and alpha was set at 0.05. Sensitivity analysis showed that the study was able to detect medium effect sizes with 80% power, with alpha set at 0.05.