QoL and mental health across different causes of anaphylaxis
There were no significant differences across the different causes of anaphylaxis for reported stress or anxiety but there were significant differences for depression across food, venom, medication or spontaneous causes of anaphylaxis, F(3,134)=3.04, p<0.05. Post hoc tests showed that those with anaphylaxis to medication reported significantly greater depression than those reacting to bee or wasp venom.
There were significant differences across different causes for general physical QoL as measured by the WHOQoL BREF, F (3,128)4.40, p<0.01, but not for social, psychological or environmental QoL. Post hoc tests showed that those with anaphylaxis to medication reported significantly worse physical QoL than those reporting anaphylaxis to venom (p<0.01).
For anaphylaxis specific overall QoL, there were significant differences across food, venom, medication or spontaneous causes of anaphylaxis, F(3,124)=6.50, p<0.001. Post hoc tests showed that those with anaphylaxis to food had significantly poorer QoL than those reacting to bee or wasp venom (p<0.02) or medication (p<0.05). Those with spontaneous anaphylaxis reported significantly poorer QoL than those with anaphylaxis to venom (p<0.01) or medication (p<0.05).
For the sub-domains of the A-QoL-Adults scale, there were significant differences across the different causes for Limitations on Life, F(3,129)=7.34, p<0.001, Social QoL, F(3,130)=3.83, p<0.01 and Emotional QoL, F(3,131)=4.49, p<0.01. Post hoc tests showed that those with spontaneous anaphylaxis reported poorer social QoL (p<0.05) and emotional QoL (p=0.01) than those reacting to venom. Those reacting to food reported poorer emotional QoL (p<0.01) than those reacting to venom and greater limitations on life compared to those reacting to venom (p<0. 05) or medication (p<0.001). Finally, those with spontaneous anaphylaxis reported greater limitations on life than those reacting to medication as a cause (p<0.05) (Table 4).