loading page

Infectious endocarditis of the mitral valve with hypertrophic cardiomyopathy in Costello syndrome
  • +1
  • Shinichi Ishida,
  • Masato Mutsuga,
  • Takashi Fujita,
  • Kei Yagami
Shinichi Ishida
Gifu Kenritsu Tajimi Byoin

Corresponding Author:shin1dinho@yahoo.co.jp

Author Profile
Masato Mutsuga
Nagoya University Graduate School of Medicine Faculty of Medicine
Author Profile
Takashi Fujita
Gifu Kenritsu Tajimi Byoin
Author Profile
Kei Yagami
Gifu Kenritsu Tajimi Byoin
Author Profile

Abstract

Costello syndrome is a rare congenital disease caused by activating germline mutations, and it is often associated with cardiac abnormalities. A 17-year-old male, who had a history of Costello syndrome, presented with persistent fever. The vegetation attached to anterior mitral leaflet was detected, and antibiotic therapy was administered as treatment for infectious endocarditis. However, it was difficult to manage his heart failure owing to the worsening of mitral valve regurgitation. Therefore, mitral valve repair with vegetation resection was performed. His hypertrophic cardiomyopathy and systolic anterior motion caused left ventricle outflow tract obstruction. A floating stitch on the anterior mitral leaflet from the posterior ring annulus was effective. Herein, we report a successfully repaired case of infectious endocarditis on the mitral valve with hypertrophic cardiomyopathy complicated by Costello syndrome.