Comparison of NICE and FMF screening algorithms
Of the total cohort, 766 (12.8%) pregnancies were considered high risk
for PE based on the NICE screening method, of which 577 (75.3%) were
appropriately prescribed aspirin prophylaxis. Among the 24.7% who were
screen positive and not prescribed aspirin, 75% had at least one major
risk factor as described by the NICE recommendations. (Table 1)
Using a risk cut-off of ≥1:100, 950 (15.9%) pregnancies were considered
high-risk based on the FMF algorithm. 391 (6.5%) of these pregnancies
were also screen positive by NICE criteria. This resulted in a third of
the women screening positive using the FMF algorithm receiving aspirin
prophylaxis. In comparison to the NICE method, the FMF screening
algorithm identified 87 additional pregnancies complicated by PE that
may have benefitted from first trimester aspirin prophylaxis. (Table 1)