Extramedullary hematopoiesis (EMH) represents the production of blood cells outside of the bone marrow and occurs in beta thalassemia major. Although EMH usually occurs in the liver, spleen, and lymph nodes, it may also occur in the spinal canal or sacral bone lead to neurological complications

As the clinical course of COVID-19 infection in SCD patients is not clear, close monitoring is essential. We emphasize that RBC exchange should be offered early to avoid possible deterioration. We present a case of COVID-19 infection in a SCD patient causing severe hemolysis, that improved after RBC exchange.

We are reporting an African female patient who is found to has thrombocytopenia secondary to iron deficiency anemia (IDA), and she responded to iron replacement therapy initially with a transient drop in platelets, followed by a gradual rise in platelets till platelets reached to the normal level.

We report a 56-year-old male with methemoglobinemia and hemolytic anemia, secondary to fava bean ingestion. Methylene blue administration worsened the hemolysis as he was G6PD deficient but not diagnosed before. We have discussed the mechanism of hemolysis in such patients and the management of such cases.

The atrial septal aneurysm is a rare cardiac abnormality that is usually detected during routine echocardiography or evaluation of cases with thromboembolism. We report a 62 years old male who presented with abdominal pain and bleeding per rectum found to have ischemic colitis and atrial septal aneurysm on transesophageal echocardiogram.

Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. Chronic myelogenous leukemia (CML) is usually diagnosed on routine complete blood count as it is typically asymptomatic. However, it can cause multiple signs and symptoms. We present a patient with appendicitis revealing CML during his workup for abdominal pain.

Eltrombopag is relatively new drug used in Thrombocytopenia. Its dose should be adjusted based on platelets count. It should be stopped when platelets count reach 400,000/mm³. Here, we share our case report of stopping Eltrombopag based on platelets increment in secondary reactive thrombocytosis irrespective of Eltrombopag treatment.

Background Obesity is a chronic disease that is increasing in prevalence in adults, adolescents, and children and it is now considered to be a global epidemic. Current recommendation for treatment of Chronic Myeloid Leukemia (CML) does not take in consideration the weight of the patient and doses ofTKIs

Polycythemia vera (PV) characterize by an increase in RBCs and hemoglobin concentration. The typical presentation of PV is a plethora and thrombosis. Sites of thrombosis are Lower limbs. Rare sites of thrombosis are sagittal sinus. We report a case of 52 years old women with polycythemia complicated with sagittal thrombosis

All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though those patients were considered vulnerable, a clear prognosis, as well as the possibility of reinfection, was not mentioned before. We report here the first case of Thalassemia beta major who had COVID-19 reinfection detected by screening.

1.7% of myeloproliferative neoplasms are associated with autoimmune conditions. Association of myasthenia gravis (MG) with chronic myeloid leukemia is reported, but its association with polycythemia vera (PV) has never been reported. We report two patients who had MG and PV with JAK2V617F mutation. Both had splenomegaly but no thymoma.

we reported an18 years old male with beta thalassemia major who presented with back pain progressive over 1 month associated with numbness in thighs, together with lower limbs weakness and difficulty walking. he also mentioned having difficulty in passing urine. he received radiotherapy which results in significant improvement in symptoms