Impact of pretransplant recipient HBsAb titers
Eighty-seven patients with protective immunity to HBV before
transplantation were divided into two groups according to the status of
HBsAb after transplantation: group A was composed of 55 (63.2%, 55/87)
patients who became HBsAb negative, and group B was composed of 32
(36.8%, 32/87) patients who maintained HBsAb positivity one year after
transplantation. The initial HBsAb titers in group B were significantly
higher than those in group A (287.1 vs. 154.6 IU/L, P = 0.015).
The ROC curve was used to evaluate the cutoff value of the HBsAb titer
before HSCT for the prediction of HBsAb disappearance within one year
after HSCT. The area under the curve was 0.656 (P = 0.015), with a
sensitivity of 62.5% and a specificity of 65.5%, and the cutoff value
for the pretransplant HBsAb titer was
207.5 IU/L.