Impact of pretransplant recipient HBsAb titers
Eighty-seven patients with protective immunity to HBV before transplantation were divided into two groups according to the status of HBsAb after transplantation: group A was composed of 55 (63.2%, 55/87) patients who became HBsAb negative, and group B was composed of 32 (36.8%, 32/87) patients who maintained HBsAb positivity one year after transplantation. The initial HBsAb titers in group B were significantly higher than those in group A (287.1 vs. 154.6 IU/L, P = 0.015).
The ROC curve was used to evaluate the cutoff value of the HBsAb titer before HSCT for the prediction of HBsAb disappearance within one year after HSCT. The area under the curve was 0.656 (P = 0.015), with a sensitivity of 62.5% and a specificity of 65.5%, and the cutoff value for the pretransplant HBsAb titer was 207.5 IU/L.