Postoperative thoracic aortic graft infection (TAGI) is a serious and potentially fatal complication. The classical approach is to replace the infected graft. However, this approach has a high mortality rate. Alternatively, treatment of TAGI without graft replacement can be performed. Herein, we present successful treatment of the case of a 72-year-old patient with mediastinitis and graft infection after type A aortic dissection operation for whom we performed omental flap coverage following vacuum-assisted wound closure therapy without graft replacement. The patient had an uneventful postoperative course and remained infection free for the last 36 months to date.