Lactobacillus and Nrf2
In mice, several strains of Lactobacillus were found to regulate
Nrf2 in models of ageing 49, cardioprotective effects50, and non-alcoholic fatty acid liver disease51. Lactobacillus plantarum CQPC11 - isolated
from Sichuan pickled cabbages - antagonizes oxidation and ageing in mice52. Lactobacillus protects against ulcerative colitis
by modulation of the gut microbiota and Nrf2/Ho-1 pathway53. The sugary kefir strain, Lactobacillus maliAPS1, \soutameliorated ameliorates? hepatic steatosis by regulation of
Nrf2 and the gut microbiota in rats 54. In
vitro studies have also found an effect of Lactobacilli mediated
by Nrf2 55-57. Interestingly, the synbiotic
combination of prebiotic grape pomace extract and probioticLactobacillus sp. \soutreduced reduces? intestinal inflammatory
markers.58