Legend to Figures
Figure 1. Dot and box plot (median and 95% CI) of sputum cell PAPPA mRNA expression scores in: (A) never-smoking severe asthma (NSA), smoking and ex-smoking SA (SSA), mild-moderate asthma (MMA) and healthy controls (HC); (B) in eosinophilic, neutrophilic, mixed and pauci-granulocytic inflammation in asthmatics and healthy controls (HC); and (C) in the transcriptomic-associated clusters (TAC1, TAC2 and TAC3) in U-BIOPRED. Sputum PAPPA protein levels in NSA, SSA, MMA and HC subjects (D); eosinophilic, neutrophilic, mixed and pauci airway inflammation subjects and HC (E); in T2-high and T2-low asthmatic subjects and HC subjects (F).
Figure 2. Receiver operating characteristic (ROC) curves analysis of the sensitivity and specificity of serum (A) and sputum (B) PAPPA levels for sputum eosinophilic airway inflammation (sputum eosinophils >1.49%) in asthmatic subjects. AUC, Area under the curve.