Werner J Pichler, MD
ADR-AC
Holligenstr 91
3008 Bern
Switzerland
e-mail:
werner.pichler@adr-ac.ch
Keywords: drug allergy; anaphylaxis; immediate drug reaction;
specific IgE; hapten; covalent bonds; adducts; non-covalent bindings;
fake antigen
Abbreviations: antigen-presenting cell: APC; basophil
activation test: BAT; dendritic cell: DC; drug hypersensitivity
reactions: DHR; fake antigen reactions: FAR; high affinity receptor for
IgE: FcεRI; human leukocyte antigens: HLA; human serum albumin: HSA;
mast cell: MC; neuromuscular blocking agents/muscle relaxants: NMBA;
Proton pump inhibitor: PPI; radiocontrast media: RCM; sulfamethoxazole:
SMX; T cell receptor for antigen: TCR
Word count: 3574
Acknowledgments: the author thanks Ulrika Axius, Yvonne Hari,
Oliver Hausmann, Lukas Jörg, Nicole Müller, Florian und Juliane Pichler,
Gregor Porebski, Ulrich Weber-Mani, Daniel Yerly for inspiring
discussions and Katja Martin for help in preparing the figures and text.