Study Limitations
The number of this cases series is small. Whether the procedural and long-term outcomes can be reproducible in a larger patient population is unknown.
The biophysics of radiofrequency lesion is different in healthy myocardium from that of the scarred myocardium. If the animal model with scarred myocardial tissue was created first and the techniques used in our study were then applied afterwards, the results would be more scientific and accurate. Meanwhile, lesion size by direct ethanol injection should be measured three dimensionally and the lesion geometry should be present in a full view in the animal study. However, only two dogs were assigned to test the acute lesion formation and the other two for chronic lesion pathology. Our main purpose of the animal study is to test the correlation between the lesion size and the ethanol dosage, and the homogenization property of the chronic lesion pathology. We would further the animal study as a single study project in the future.