Study Limitations
The number of this cases series is small. Whether the procedural and
long-term outcomes can be reproducible in a larger patient population is
unknown.
The biophysics of radiofrequency
lesion is different in healthy myocardium from that of the scarred
myocardium. If the animal model with scarred myocardial tissue was
created first and the techniques used in our study were then applied
afterwards, the results would be more scientific and accurate.
Meanwhile, lesion size by direct ethanol injection should be measured
three dimensionally and the lesion geometry should be present in a full
view in the animal study. However, only two dogs were assigned to test
the acute lesion formation and the other two for chronic lesion
pathology. Our main purpose of the animal study is to test the
correlation between the lesion size and the ethanol dosage, and the
homogenization property of the chronic lesion pathology. We would
further the animal study as a single study project in the future.