2.3 Edema measurement
Paw thickness was used as a measure of inflammation-induced edema
(Buritova, Honore & Besson, 1995;
Wei, Zou, Young, Dubner & Ren, 1999).
The dorsoventral thickness of each hind paw was measured with a digital
caliper. The caliper was placed at the metatarsophalangeal border and
touched, but did not squeeze, the hind paw. Contralateral paw thickness
was used as a control measure.