Abstract
Background:Kawasaki disease, a systemic vasculitis in children, may
bring serious complications. However, the etiology of KD remains
unclear. AIM2, an intracellular receptor, plays a vital role during the
infection caused by a variety of pathogens. However, its role in KD
remains unclear. The principal aim of the present research is to
concentrate on the relation between AIM2 and KD. Methods: We detected
the serum level of AIM2, IL-18 and IL-1β in all subjects by ELISA. The
conventional inflammatory indices were detected in all subjects, such as
WBC, HB, CRP and so on. Results: The serum concentrations of AIM2, IL-18
and IL-1β were notably increased in the KD group compared to the febrile
group and healthy group, respectively. And the three indicators in the
KD patients were greatly reduced after interpreted with IVIG.
Furthermore, the expressions of IL-18 and IL-1β were positively
correlated with AIM2. Meanwhile,the cutoff value of serum AIM2 level
for the diagnosis of KD was 541.90 ng/L with the specificity of 60% and
sensitivity of 92.5 %,compared to the febrile controls. And the area
under curve (AUC) of AIM2 was 0.771. And no difference was observed in
the CALs group when compared without the CALs group. Conclusions: The
serum AIM2, IL-18 and IL-1β might play a critical role during the
progress of KD. AIM2 can be considered as a candidate indicator for
Kawasaki disease diagnosis. Keywords: AIM2 · IL-18· IL-1β · Kawasaki
disease · Intravenous immunoglobulin ·coronary artery lesions