TNFR1 factor
By examining TNFR ratio on days 7, 14, 21 and 28 compared to
pre-transplantation, it was observed that this level was enhanced in
both MSCs + HSC and HSC groups on day 7 which could be caused by
conditioning regimens. Since TNF-α is one of the most important factors
of inflammation, following mucosal and subsequent epithelium injury and
initiation of inflammatory pathways, the alternative marker of this
inflammatory factor also increases in the plasma of transplanted
patients. In the mesenchymal stem cell recipient group, this ratio
decreased earlier than in the HSCs alone. However, there was no
significant difference in the ratio of TNFR1 on different days between
two groups (Table.5)
According to Table 6 (considering p value: 0.05) both groups showed
there was no significant difference in mean values of TNFR between two
groups on different days.
DNAM-1
factor
Due to the important role of the interaction between DNAM-1 and its
ligand in the development of aGvHD, patients with higher DNAM-1 levels
are assumed to exhibit higher GvHD. All patients selected for this study
had a DNAM-1 level higher than 8 ng/ml at baseline (above the mean in
normal subjects). Based on previous studies and the prognostic role of
this marker in the incidence of GvHD, patients with higher level of
DNAM-1 were selected for co-transplantation of MSCs and HSCs. According
to Table no. 7, comparing the mean DNAM factor for each day in two
groups, a significant difference is shown on day 7 with P-VALUE equal to
0.03 and less than 0.05. But in other days we did not see a significant
difference between two groups with P-VALUE higher than 0.05( Figure 5).