Overall death (double-arm randomised and observational studies)
Comparing the results of two randomised control studies12,13 with a total of 269 patients, we noted no significant difference in overall death rate between the FFR-guided CABG as compared to CAG guided CABG (RR: 0.86, 95% CI: 0.19 to 3.95, p = 0.85) (Figure 2A). Analysing the data of two double-arm observational studies14,15 and 1023 patients we observed significantly lower rates of overall death with the use of FFR-guided CABG as compared to CAG guided CABG (RR: 0.62, 95% CI: 0.40 to 0.95,p = 0.03) (Figure 2A). The results of all 4 studies with a total of 1292 patients also showed that the rates of overall death were significantly lower in the FFR-guided CABG group (RR: 0.63, 95% CI: 0.42 to 0.96, p = 0.03) (Figure 2A).