Viruses are considered as one of the primary drivers for human evolution. Humans in return have also offered them an ideal habitat for their growth and evaluation. However, both, humans and viruses are diverse, astute, competitive, and avaricious in nature, which engage them in a never-ending battle. Today, the world goes to win the battle against COVID-19 for sure. However, this never ending merciless battle between viruses and humans looks like an arms race for their survival in which neither a virus wins nor a human but each battle provides them an opportunity to bounce back for the next.

Throughout the history, pandemics have played a significant role in reshaping human civilizations. In this series, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a new coronavirus strain causing novel Coronavirus-19 (COVID-19) disease that has brought the entire world to its knees. The uncertainty revolving around the virus can spark beyond our imagination if not handled appropriately. Immunity against COVID-19 can be achieved in two ways – through natural infection or through vaccination against COVID-19. The second way is the most preferred one, is to develop a safe and effective vaccine and practice mass vaccination without enduring the significant loss of precious lives. However, efficiently developing and delivering a perfect vaccine on time under tremendous pressure to meet millions of expectations is not an easy task as there are many elephants in the room. Besides, we do need a strong, vigilant, and people-friendly healthcare delivery system to translate the vaccine into vaccination without any discrimination. Until such time the vaccine is developed and mass administration takes place the silver bullets against COVID-19 would be symptomatic treatment, avoid mass gathering, social distancing, frequent hand washing, wearing masks and gloves, and generating COVID-19 related awareness in the society.