3 Molecular Design of Baculovirus Expression Vectors and Cell Lines For Production of rAAV
In the last two decades, various molecular design approaches have been used to achieve efficient AAV production employing IC-BEVS platform. Building upon intrinsic advantages of this platform, the active efforts were directed towards achieving higher expression stability, improved yield, and streamlining manufacturing processes. Below, we summarize the progressive development of various strategies and highlight features that might be of consideration when using IC-BEVS for AAV production.