3 Molecular Design of Baculovirus Expression Vectors and Cell
Lines For Production of rAAV
In the last two decades, various molecular design approaches have been
used to achieve efficient AAV production employing IC-BEVS platform.
Building upon intrinsic advantages of this platform, the active efforts
were directed towards achieving higher expression stability, improved
yield, and streamlining manufacturing processes. Below, we summarize the
progressive development of various strategies and highlight features
that might be of consideration when using IC-BEVS for AAV production.