Conclusion
This case highlights the importance of early suspicion ofCryptococcus neoformans infection and other opportunistic infections in immunocompromised patients, putting in mind that patients with Cryptococcaemia have a high risk of mortality within 30 days, which warrants the use of corticosteroid and immunomodulatory drugs in a critically ill patient with COVID-19. In the current scenario, the use of immunosuppressive therapy should be justified and to be alert for opportunistic infection like Cryptococcus neoformans infection, which can lead to sepsis and mortality.