Background:
Cryptococcus neoformans are basidiomycetous; encapsulated yeasts are classified into 4 serotypes according to their capsule. (1) the way of the infection is by inhalation of basidiospore form or small, poorly encapsulated yeasts. (2) Cryptococcus neoformans infection typically happens among immunocompromised patients and meningoencephalitis is the typical manifestation of cryptococcosis among HIV patients. (3, 4) in immunocompetent, the infection can be subclinical and a study on postmortem immunocompetent just showed small granulomatous disease in the lung without disseminating the infection. (5, 6) We describe a case of a patient with COVID-19 who developed Cryptococcemia while being treated by immunosuppressive treatment.