FIGURE LEGEND
Fig. 1 – Astrocyte-neuron-oligodendrocyte energy metabolism
interactions. Glucose in neurons is primarily used for adenosine
triphosphate (ATP) production and is metabolized into lactate in
astrocytes. The glucose transporters (GLUTs) mediate the transportation
of glucose into cells. GLUT1, located in cerebral endothelial cells,
transits glucose from the blood into the brain tissue. GLUT1 also
mediates the entrance of glucose into astrocytes and oligodendrocytes.
Glucose is transported into neurons via GLUT3. Monocarboxylate
transporters (MCTs) and connexin (Cx) contribute to
astrocyte-neuron-oligodendrocyte lactate transport. MCT1 and MCT4 in
astrocytes release lactate, which diffuses into neurons due to the
lactate gradient and is actively taken up by neurons via the MCT2.
Additionally, MCT1 in the myelin cooperates with MCT2 in the axon to
translate the lactate from oligodendrocytes to neurons. Therefore,
glucose and lactate, together with their transporters, contribute to the
astrocyte-neuron-oligodendrocyte energy metabolism interactions. TCA,
tricarboxylic acid; PPP, pentose phosphate pathway; LDH, lactate
dehydrogenase. From Zhang et al26, with permission.
Figure 1 Supplement. Unweighted and weighted standardized mean
differences of propensity score model; IPTW = inverse probability of
treatment wieghting
Table 1 – Preoperative and perioperative variables.