Methaemoglobinaemia and the radical curative efficacy of
8-aminoquinoline antimalarials
- Nicholas White
, - James Watson,
- Kevin Baird
Nicholas White
Faculty of Tropical Medicine, Mahidol Iniversity
Corresponding Author:nickw@tropmedres.ac
Author ProfileJames Watson
Mahidol University Faculty of Tropical Medicine
Author ProfileAbstract
Methaemoglobin results from the oxidation of ferrous to ferric iron in
the centre of the haem moeity of haemoglobin. The production of
dose-dependent methaemoglobinaemia by 8-aminoquinoline antimalarial
drugs appears to be associated with, but is not directly linked to
therapeutic efficacy against latent vivax and ovale malarias. Iatrogenic
methaemoglobinaemia may be a useful pharmacodynamic measure in
8-aminoquinoline drug and dose optimization.22 Nov 2021Submitted to British Journal of Clinical Pharmacology 24 Nov 2021Submission Checks Completed
24 Nov 2021Assigned to Editor
14 Dec 2021Reviewer(s) Assigned
17 Dec 2021Review(s) Completed, Editorial Evaluation Pending
17 Dec 2021Editorial Decision: Revise Minor
18 Dec 20211st Revision Received
20 Dec 2021Submission Checks Completed
20 Dec 2021Assigned to Editor
20 Dec 2021Review(s) Completed, Editorial Evaluation Pending
31 Dec 2021Editorial Decision: Accept
Jun 2022Published in British Journal of Clinical Pharmacology volume 88 issue 6 on pages 2657-2664. 10.1111/bcp.15219 
