Aortic root replacement to treat type A aortic dissection: a comparison
of mid-term outcomes between composite-valve-grafts and porcine aortic
roots
Abstract
Background Porcine aortic roots (PAR) have been reported in the
literature with acceptable short and long-term outcomes for the
treatment of aortic root aneurysms. However, their efficacy in type A
aortic dissection (TAAD) is yet to be defined. Methods Using data from a
locally collated aortic dissection registry, we compared the outcomes in
patients undergoing aortic root replacement for TAAD using either of two
surgical options: i) PAR or ii) composite valve grafts (CVG). A
retrospective analysis was conducted for all procedures in the period
2005-2018. Results A total of 252 patients underwent procedures for TAAD
in the time period. Sixty-five patients had aortic root replacements
(PAR n=30, CVG n=35). Between group comparisons identified a younger CVG
group (50.5 vs 64.5, p<0.05) although all other covariates
were comparable. Operative parameters were comparable between the two
groups. The use of PAR did not significantly impact operative mortality
(OR 0.93, 95% CI 0.22-3.61, p=0.992), stroke (OR 2.91, 0.25 – 34.09,
p=0.395), re-operation (OR 0.91, 95% CI 0.22 – 3.62, p=0.882) or
length of stay (coef 2.33, -8.23 – 12.90, p=0.659) compared to CVG.
Five-year survival was similar between both groups (PAR 59% vs CVG
69%, p=0.153) and re-operation was negligible. Echocardiography
revealed significantly lower aortic valve gradients in the PAR group
(8.69 vs 15.45 mmHg, p<0.0001), and smaller left ventricular
dimensions both at 6 weeks and 1 year follow up (p<0.05).
Conclusions This study highlights the comparable short and mid-term
outcomes of PAR in cases of TAAD, in comparison to established therapy.