The ongoing outbreak of Coronavirus disease 2019 (COVID-19) has already caused a worldwide pandemic, World Health Organization has raised COVID-19 global risk to very high. We aimed to share the Joint Prevention and Control Mechanism taken in Mainland China and evaluate the effectiveness. Data were collected from the daily epidemic reports released by the national and provincial health commissions of China from January 21 to March 26, 2020. Global data were collected from daily situation reports by World Health Organization. Under the first-level public health emergency response, great achievements have been made in controlling the spread of COVID-19 in Mainland China. As of March 26, the daily new deaths were less than 50 in nationwide recently. However, it is still a major challenge worldwide. The comprehensive and powerful control measures taken by Mainland China have proved to be effective and might be applicable to other regions.