Role of BLK in the human body
Signalling via BLK performs a critical position in transmitting indicators through floor immunoglobulins and provide the supports to seasoned-B to pre-B transition, as well as the signalling for increase arrest and apoptosis downstream of the B-cell receptor. Phosphorylation of CD79A at ’Tyr-188’and ’Tyr-199’, as well as CD79B at ’Tyr-196’ and ’Tyr-207’ is done by specific binding of BLK and itphosphorylates in addition to the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C. Alongwith FYN and LYN, it performs an essential position in the pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (Clark, Mandal, Ochiai, & Singh, 2014). BLKcontributes to BTK activation by using not directly stimulating BTK intramolecular autophosphorylation. In islets of the pancreas, acts as a modulator of beta-cells characteristic through the up-law of PDX1 and NKX6-1 and consequent stimulation the secretion of insulin in reaction to glucose. Phosphorylates CGAS, promoting retention of CGAS inside the cytosol(Kurosaki, 2002).The biological function of BLK consist of B cell receptor signalling pathway, cell differentiation, intracellular signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of insulin secretion, regulation of B cell receptor signalling pathway, regulation of B cell receptor signalling pathway, regulation of cell population proliferation receptor of transmembrane protein tyrosine kinase signalling pathway (JADWIN, 2017).