Analysis of Isoelectric point and charges of the residues
We have analysed isoelectric point and charges of every residue on blk
using the Geneious prime. This plot can clearly define the
Hydrophobicity of the residues along with its isoelectric point, both
play an important role in drug designing. We have also categorised the
Transmembrane permeability and plotted its affinity at outside, inside
and on the plasma membrane of the cell. An amino acid charge is
basically defining the charge per residues which can be added for the
cumulative analysis of the receptor. The cumulative of hydrophobicity at
each residue could reveal a lot about the drug design for BLK to
upregulate and downregulate in the human body. This graph is depicting
the charge, TM along with the secondary structure for the better
understanding of the system. For the detailed analysis of the domains of
the Human BLK, we have plotted all the annotations along with the domain
region on the sequence (Fig. 11).
Fig. 11 Graphical representation of annotations of the BLK