Role of BLK in the human body
Signalling via BLK performs a critical position in transmitting
indicators through floor immunoglobulins and provide the supports to
seasoned-B to pre-B transition, as well as the signalling for increase
arrest and apoptosis downstream of the B-cell receptor. Phosphorylation
of CD79A at ’Tyr-188’and ’Tyr-199’, as well as CD79B at ’Tyr-196’ and
’Tyr-207’ is done by specific binding of BLK and itphosphorylates in
addition to the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C.
Alongwith FYN and LYN, it performs an essential position in the
pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation
(Clark, Mandal, Ochiai, & Singh, 2014).
BLKcontributes to BTK activation by using not directly stimulating BTK
intramolecular autophosphorylation. In islets of the pancreas, acts as a
modulator of beta-cells characteristic through the up-law of PDX1 and
NKX6-1 and consequent stimulation the secretion of insulin in reaction
to glucose. Phosphorylates CGAS, promoting retention of CGAS inside the
cytosol(Kurosaki, 2002).The biological
function of BLK consist of B cell receptor signalling pathway, cell
differentiation, intracellular signal transduction, peptidyl-tyrosine
autophosphorylation, peptidyl-tyrosine phosphorylation, positive
regulation of insulin secretion, regulation of B cell receptor
signalling pathway, regulation of B cell receptor signalling pathway,
regulation of cell population proliferation receptor of transmembrane
protein tyrosine kinase signalling pathway
(JADWIN, 2017).