Atherosclerosis is a serious disease that starts with a local lesion in the vessels and progressesto a heart attack. The recent increase in heart attack disease and the increase i n deaths related to it makes it important to discover drug candidate ligands to be detected against the receptors determined in this disease. In this study, chemical calculation method was used to determine the interaction with Atherosclerosis receptors determined by literature studies and the bonds to be formed at the molecular level and the inhibition mechanism.The foods, spices and active ingredients in various medicinal plants that we consume as daily food supplements were identified as ligands at the end of the research conducted with the literature review, and the inhibition effects on the receptors that suppress the distribution of cholesterol, which is one of the biggest causes of atherosclerosis, to the cells through the blood were determined by comparing the currently used reference drugs. The data obtained from here is important in terms of determining drug candidate active substances in experimental and clinical studies to be conducted on atherosclerosis, preventing time and substance loss and giving direction.

Background and Purpose Atherosclerosis is a serious disease that starts with a local lesion in the vessels and progressesto a heart attack. The recent increase in heart attack disease and the increase i n deaths related to it makes it important to discover drug candidate ligands to be detected against the receptors determined in this disease. Methods and Results In this study, chemical calculation method was used to determine the interaction with Atherosclerosis receptors determined by literature studies and the bonds to be formed at the molecular level and the inhibition mechanism.The foods, spices and active ingredients in various medicinal plants that we consume as daily food supplements were identified as ligands at the end of the research conducted with the literature review, and the inhibition effects on the receptors that suppress the distribution of cholesterol, one of the biggest causes of atherosclerosis, to the cells through the blood were determined by comparing the currently used reference drugs. The data obtained from here is important in terms of determining drug candidate active substances in experimental and clinical studies to be conducted on atherosclerosis, preventing time and substance loss and giving direction.

Background and Purpose: Oleuropein is found in olive trees and in the leaves of olive trees. It may have an important role in the treatment and possible prevention of of Alzheimer’s disease. Applied Approach: The aim of this study is to determine the chemical properties of oleuropein and determine the reactivity of this substance as well as Oleuropein’s inhibition effect on AChE.BChE. Key Results: DFT (Density functional theory), HF (Hartree-Fock) and docking methods were used to measure the chemical properties of oleuropein. The structures of the compounds were fully optimized by using the above-mentioned methods and the results were evaluated. Oleuropein is an unstable molecule and is prone to degredation possibly due to it containing a phenolic structure. Conclusion and Implications:The results of the present study indicate that it may play an important role in the treatment of Alzheimer’s disease.