Funding:
The authors disclose receipt of the following financial support for the research, authorship and/or publication of this article: this study was supported by the Key Research and Development Program of Shandong Province (2019GSF108090); the National Natural Science Foundation of China (81801476); the Natural Science Foundation of Shandong Province (ZR2019PH054, ZR2017BH046); the Medical and Health Science and Technology Development Plan of Shandong Province (2016WS0411, 2016WS0404) and the Jinan Science and Technology Development Program (201805026).