Figure legends
Figure 1: showed the effect on the blood glucose level of
studies of Prunus amygdalus extract and glibenclamide in Oral
Glucose Tolerance Test (OGTT). a: showed the blood glucose
level at different time interval and b: Area under curve (AUC) on the
different time interval.
Figure 2: showed the effect on the blood glucose level ofPrunus amygdalus extract and glibenclamide in STZ induced type II
Diabetic mellitus rats. a: showed the blood glucose level at
end of the experimental period and b: showed the effect on the
blood glucose level (% inhibition). The comparisons were made by ANOVA
followed by Dunnett’s test. zP < 0.05 is
considered significant, yP < 0.01 is
considered very significant, xP < 0.001 is
considered extremely significant.
Figure 3: showed the effect on the body weight effect ofPrunus amygdalus extract and glibenclamide in STZ induced type II
Diabetic mellitus rats. a: showed the body weight at end of the
experimental period and b: showed the effect on the body weight
(% inhibition). The comparisons were made by ANOVA followed by
Dunnett’s test. zP < 0.05 is considered
significant, yP < 0.01 is considered very
significant, xP < 0.001 is considered
extremely significant.
Figure 4: showed the pancreas histopathology of normal and
treated group rats. a: showed the normal group rat
histopathology, b: showed the histopathology of normal group
rat received PA (200 mg/kg), c: showed the STZ induced
type II Diabetic mellitus rat histopathology, d: showed the
histopathology of STZ induced type II Diabetic mellitus receivedPA (50 mg/kg), e: showed the histopathology of STZ
induced type II Diabetic mellitus received PA (100 mg/kg),f: showed the histopathology of STZ induced type II Diabetic
mellitus received PA (200 mg/kg) and showed the histopathology of
STZ induced type II Diabetic mellitus received glibenclamide (2.5 mg/kg)
Supplementary figure 1: Effect of extraction temperature, time
and solvent concentration (A), (B) and ratio (C) on DPPH free radical
scavenging activity of Prunus amygdalus extract.
Supplementary figure 2: Effect of extraction temperature, time
and solvent concentration (A), (B) and ratio (C) on ABTS free radical
scavenging activity of Prunus amygdalus extract.
Supplementary figure 3: showed the molecular docking studies ofPrunus amygdalus extract and glibenclamide against DPP4 catalytic
site (PDBID-2G63). a: Binding interaction of Rutin against DPP4
catalytic site, b: Rutin against DPP4 catalytic site, c: Binding
interaction of glibenclamide against DPP4 catalytic site, d: Ligplot of
Glibenclamide against DPP4 and e: Superimposition of Rutin with
glibenclamide against DPP4 catalytic domain.
Supplementary figure 4: showed the molecular docking studies ofPrunus amygdalus extract and glibenclamide against GLUT1
catalytic site (PDBID-5EQG). a: Binding interaction of Rutin
against GLUT1 catalytic site, b: Ligplot Rutin against GLUT1 catalytic
site, c: Binding interaction of glibenclamide against GLUT1 catalytic
site, d: Ligplot of Glibenclamide against GLUT1 and e: Superimposition
of rutin with glibenclamide against GLUT1 catalytic domain.
Supplementary figure 5: showed the molecular docking studies ofPrunus amygdalus extract and glibenclamide against PPARY
catalytic site (PDBID-2PRG). a: Binding interaction of Rutin
against PPARY catalytic site, b: Rutin against PPARY catalytic site, c:
Binding interaction of glibenclamide against PPARY catalytic site, d:
Ligplot of Glibenclamide against PPARY and e: Superimposition of Rutin
with glibenclamide against PPARY catalytic domain.