We investigate a new class of stochastic integro-differential equations driven by L´evy noise. Particularly, based on Schauder’s fixed point theorem, the existence of square-mean almost automorphic mild solution in distribution is obtained by using some conditions which are weaker than Lipschitz conditions. Our result can be seen as a generalisation of the result of [17] and [28] based on the compactness of solution semigroup operators of our slightly different stochastic model. We provide an example to illustrate ours results.