References
Aguirre-Ezkauriatza EJ, Aguilar-Yáñez JM, Ramírez-Medrano A, Alvarez MM.
2010. Production of probiotic biomass (Lactobacillus casei ) in
goat milk whey: Comparison of batch, continuous and fed-batch cultures.
Bioresource Technology.101:2837–44.
Babi DK, Cruz MS, Gani R. 2016. Chapter 2 - Fundamentals of Process
Intensification: A Process Systems Engineering View. Process
Intensification in Chemical Engineering. X, 336 p. DOI
10.1007/978-3-319-28392-0_2
Berenjian A, Mahanama R, Talbot A, Regtop H, Kavanagh J, Dehghani F.
2014. Designing of an Intensification Process for Biosynthesis and
Recovery of Menaquinone-7 Appl Biochem Biotechnol. 172:1347–1357
Callewaert R, De Vuyst L. 2000. Bacteriocin production withLactobacillus amylovorus DCE 471 is improved and stabilized by
fed-batch fermentation. Applied and Environmental Microbiology.
66(2):606–13.
Campos IB, Herd M, Moffitt KL, Lu YJ, Darrieux M, Malley R, Leite LCC,
Gonçalves VM. 2017. IL-17A and complement contribute to killing of
pneumococci following immunization with a pneumococcal whole cell
vaccine. Vaccine. 35: 1306-1315.
Carvalho SM, Kuipers OP, Neves AR. 2013. Environmental and nutritional
factors that affect growth and metabolism of the pneumococcal serotype 2
strain D39 and its nonencapsulated derivative strain R6. Plos One.
8(3):1-15.
Chang HN, Yoo IK, Kim BS. 1994. High density cell culture by
membrane-based cell recycle. Biotech. Adv. 12:467-87.
ClinicalTrials.gov [Internet]. Bethesda, MD, USA: U.S. National
Library of Medicine from National Institutes of Health (NIH); 2014
[update 2014 May 6]. Available from:
https://clinicaltrials.gov/ct2/show/NCT01537185.
Ding S, Tan T. 2006. L-lactic acid production by Lactobacillus
casei fermentation using different fed-batch feeding strategies.
Process Biochemistry. 41:1451–4.
Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C,
Konradsen HB, Nahm MH. 2015. Pneumococcal capsules and their types:
past, present, and future. Clin Microbiol Rev. 28 (3): 871-899.
Gogola-Kolling VMR, Zanardo RT, Carmo TS, Zampoli ND, Figueiredo DB,
Gonçalves VM. 2014. Improved capsular polysaccharide production byStreptococcus pneumoniae serotype 14 using continuous
cultivation. Biochem Eng J. 91:16–22.
Gonçalves VM, Dias WO, Campos IB, Liberman C, Sbrogio-Almeida ME, Silva
EP, Cardoso Jr. CP, Alderson M, Robertson G, Maisonneuve JF, Tate A,
Anderson P, Malley M, Fratelli F, Leite LCC. 2014. Development of a
whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and
stability. Vaccine. 32:1113–1120.
Gonçalves VM, Zangirolami TC, Giordano RLC, Raw I, Tanizaki MM, Giordano
RC. 2002. Optimization of medium and cultivation conditions for capsular
polysaccharide production by Streptococcus pneumoniae serotype
23F. Appl Microbiol Biotechnol. 59:713–7.
John RP, Nampoothiri KM, Pandey A. 2007. Fermentative production of
lactic acid from biomass: an overview on process developments and future
perspectives. Appl Microbiol Biotechnol. 74:524–534.
Kwon S, Yoo IK, Lee WG, Chang HN, Chang YK. 2001. High-Rate Continuous
Production of lactic acid by Lactobacillus rhamnosus in a
two-stage membrane cell-recycle bioreactor. Biotechnology and
Bioengineering. 73(1):25-34.
Leal MM, Pereira DSG, Jessouroun E, Couto MAPG, Pereira N. 2011.
Investigation of cultivation conditions for capsular polysaccharide
production by Streptococcus pneumoniae serotype 14. Electronic
Journal of Biotechnology. 14(5):1-7.
Liberman C, Takagi M, Cabrera-Crespo J, Sbrogio-Almeida ME, Dias WO,
Leite LCC, Gonçalves VM. 2008. Pneumococcal whole-cell vaccine:
optimization of cell growth of unencapsulated Streptococcus
pneumoniae in bioreactor using animal-free medium. J Ind Microbiol
Biotechnol. 35(11):1441-1445.
Liberman C, Kolling D, Sari RS, Takagi M, Cabrera-Crespo J, Sbrogio
Almeida ME, Pradella JGC, Leite LCC, Gonçalves VM. 2011. Use of soy
peptones for Streptococcus pneumoniae cultivation for vaccine
production. In: Maxwell JE, editor. Soybeans: Cultivation, Uses and
Nutrition. New York. New Science Publishers Inc.; Cap. 17, p. 415-26.
Lu YJ, Yadav P, Clements JD, Forte S, Srivastava A, Thompson CM, Seid R,
Look J, Alderson M, Tate A, Maisonneuve JF, Robertson G, Anderson P,
Malley R. 2010a. Options for inactivation, adjuvant, and route of
topical administration of a killed, unencapsulated pneumococcal
whole-cell vaccine. Clinical and Vaccine Immunology. 17(6):1005–1012.
Lu YJ, Leite L, Gonçalves VM, Dias Wde O, Liberman C, Fratelli F,
Alderson M, Tate A, Maisonneuve JF, Robertson G, Graca R, Sayeed S,
Thompson CM, Anderson P, Malley R. 2010b. GMP-grade pneumococcal
whole-cell vaccine injected subcutaneously protects mice from
nasopharyngeal colonization and fatal aspiration-sepsis. Vaccine.
28(47):7468-7475.
Lu F, Li C, Wang Z, Zhao W, Chu J, Zhuang Y, Zhang S. 2016. High
efficiency cell-recycle continuous sodium gluconate production byAspergillus niger using on-line physiological parameters
association analysis to regulate feed rate rationally. Bioresour
Technol. 220:433-41.
Lutze P, Gani R, Woodley JM. 2010. Process intensification: A
perspective on process synthesis. Chemical Engineering and Processing.
49:547–558
Min-tian G, Koide M, Gotou R, Takanashi H, Hirata M, Hano T. 2005.
Development of a continuous electrodialysis fermentation system for
production of lactic acid by Lactobacillus rhamnosus . Process
Biochemistry 40:1033-1036
Ohleyer E, Blanch HW, Wilke CR. 1985. Continuous production of lactic
acid in a cell recycle reactor. Applied Biochemistry and Biotechnology
11:317-32.
Parente E, Ricciardi A, Addario G. 1994. Influence of pH on growth and
bacteriocin production by Lactococcus lactis subsp. lactis140NWC during batch fermentation. Appl Microbiol Biotechnol.41:388-94.
Pollard AJ, Perrett KP, Beverley PC. 2009. Maintaining protection
against invasive bacteria with protein–polysaccharide conjugate
vaccines. Nature Reviews Immunology 9:213-20.
Taniguchi M, Kotani N, Kobayashi T. 1987. High-concentration cultivation
of lactic acid bacteria in fermentor with cross-flow filtration. J.
Ferment. Technol. 65(2):179-84.
Tapia F, Vázquez-Ramírez D, Genzel Y, Reichl U. 2016. Bioreactors for
high cell density and continuous multi-stage cultivations: options for
process intensification in cell culture-based viral vaccine production.
Appl Microbiol Biotechnol. 100:2121–2132
Tejayadi S, Cheryan M. 1995. Lactic acid from cheese whey permeate.
Productivity and economics of a continuous membrane bioreactor. Applied
Microbiology and Biotechnology. 43, 2:242–248.
Wee YJ, Kim JN, Yun JS, Ryu HW. 2004. Utilization of sugar molasses for
economical L(+)-lactic acid production by batch fermentation ofEnterococcus faecalis . Enzyme and Microbial Technology.
35:568–73.
Wee YJ, Ryu HW. 2009. Lactic acid production by Lactobacillus sp.
RKY2 in a cell-recycle continuous fermentation using lignocellulosic
hydrolyzates as inexpensive raw materials. Bioresource Technology.
100:4262–70.
Weinberger DM, Malley R, Lipsitch M. 2011. Serotype replacement in
disease following pneumococcal vaccination: A discussion of the evidence
Lancet. 378(9807): 1962–1973.
Xu GQ, Chu J, Wang YH, Zhuang YP, Zhang SL, Peng HQ. 2006. Development
of a continuous cell-recycle fermentation system for production of
lactic acid by Lactobacillus paracasei . Process Biochemistry.
41:2458–63.
Yesilkaya H, Spissu F, Carvalho SM, Terra VS, Homer KA, Benisty R, Porat
N, Neves AR, Andrew PW. 2009. Pyruvate formate lyase is required for
pneumococcal fermentative metabolism and virulence. Infection and
Immunity. 77(12):5418–5427.