5.1 Pharmacokinetics
Pharmacokinetics of CPT varies among individuals
(Rivory and Robert, 1995;
Rubin et al., 1995). When CPT is
administered via intravenous drip infusion, the peak plasma
concentration is attained just after the end of drug infusion and
declines in a biexponential manner with a half-life of
~7.2 h (Venditto and
Simanek, 2010). It is metabolized by carboxylesterase in the liver, and
major excretion route is thought to be non-renal. Patients who received
CPT experienced diarrhea in most cases
(Rivory et al., 1996).