4.2. Pharmacokinetics
Pharmacokinetics of terpene indole alkaloids includes intravenous
injection and continuous infusion showing triphasic clearance from
plasma. For all indole alkaloids, in alpha and beta phases, distribution
is similar, involving uptake from peripheral tissues and formed blood
elements (Emanuela et al., 2018). In the
later phase, distribution differs among indole alkaloids depending upon
drug release from different tissues. The mitotic agents are metabolized
in the liver. The plasma half-life of various indole alkaloids is
vincristine (23-85 h), vinblastine (20-64 h), vindesine (20-24 h), and
vinorelbine (18-49 h). Furthermore, all terpene indole alkaloids follow
the clearance route of biliary elimination through feces with negligible
renal clearance (Nelson, 2010).