Results
On multivariate analysis, baseline patients’ Hb, tALP, and two EORTC QLQ-C30 items, physical functioning (HR=0.970,CI=0.960-0.980,p<0.001) and dyspnea (HR=0.992,CI=0.986-0.999,p=0.023), were significantly associated with OS. In the resulting model of the multivariate analysis performed after PCA, baseline patients’ Hb, tALP and QoL-score were independent significant predictors of OS (QoL-score:HR=0.995-95%CI=0.992 – 0.998,p=0.001). The OS analysis stratified by score of baseline QoL, showed a median OS of 8 (95%CI=6-11) and 16 (95%CI=12-24) months for scores respectively below and above the cut-off value (log-rank-p<0.001). The joint model showed a significant deterioration of QoL-score during both 223Ra-therapy and follow-up period (p<0.001).