\subsection*{HIV Reverse Transcriptase}
Virtual screening results for HIV reverse transcriptase (HIV-RT) are shown in Figure~\ref{hivrt}. Again, none of the methods outperform random selection. However, FOMS displays the best early enrichment up to a true positive rate of 17\% with RDKit also achieving some early enrichment. The shape constraint queries are statistically significant and can identify enriched subsets with greater proficiency than the shape similarity methods.

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