\subsection*{Estrogen Receptor $\alpha$}

Virtual screening results for estrogen receptor $\alpha$ agonists and inhibitors are shown in Figures~\ref{eralphapot} and \ref{eralpha}. RDKit was marginally successful at identifying inhibitors with an AUC of 0.59 but the remaining methods were less successful with AUCs ranging from 0.43 to 0.52 and none of the shape-based methods exhibited early enrichment. The shape constraint queries lacked statistical significance and the most significant queries identified a large percentage of the total compounds in the database, resulting in running times that sometimes exceeded a second.
