In essence, data analysis for 15N-SIP experiments is not different from what is used in other DNA- and RNA-SIP experiments. 15N-SIP experiments were analysed succesfully using traditional comparison of clone libraries \cite{Buckley_2007} and statistical modeling of high-throughput amplicon data \cite{Pepe_Ranney_2015,Angel_2017} and qSIP \cite{Morrissey_2018}.