**Figure EV5 - Kinase activity profiles identify DNA damage responses.**
**A** All conditions displayed on the PCA first 2 components. Perturbations potentially producing DNA damage are highlighted in red. Vectors report the loadings of 3 relevant kinases.
**B** Accumulated KSEA activity of the DNA damage biomarkers ATM, PRKAA1, CHEK2 across 399 perturbations.
**C** Network displays signficantly correlated conditions. Blue edges report significant correlation between conditions involving damaging conditions. Red edges report significant anti-correlations with ATR inhibition, a kinase involved in the DNA damage response. Edge width represent the strength of the correlation.