**Figure 3 - Kinase activity profiles as fingerprints of the cell signaling state.**
**A** Perturbation scores on the first 2 PCA components based on KSEA activity profiles of 52 well-characterized kinases. Symbols flag related perturbations in different studies.
**B** Boolean logic relationships between kinase responses. Samples in 2 first components are colored by different KSEA activities. Vectors display kinase loadings.
**C** Network displays significantly correlated or anti-correlated conditions in the context of early responses after bacterial infection. The strength of the correlations - blue - and anti-correlations - red - is displayed as the edge width.
**D-E** Infection rate at 0h - left - and bacterial proliferation after 20h - right - when adding different concentrations of compounds displaying anti-correlated KSEA activity profiles with early responses after bacterial infection. Displayed significant ANOVA *p*-values evaluate differences between 3 drug concentrations and the DMSO control.
  
  
  
  