**Figure EV4 - Kinase activity profiles as signatures of the molecular response.**
**A** Fraction of significant correlations (\(FDR \lt 0.05\)) when comparing the activities across conditions for kinases at different distances in the signaling network. The network contains all kinase-substrate interactions from PhosphositePlus, HPRD and Phospho.ELM.
**B** Same but excluding kinase pairs sharing substrate residues.
**C** Differences on kinase activity profile correlation grouped by biological or technical origin. The profiles of activities for the 215 kinases are correlated by sample. Pairwise correlations between conditions assayed in different studies are grouped based on biological or technical criteria. Related conditions published in independent studies  present significantly different correlations (Student's t-test, \(p=0.002\)), than the same number of random pairs of conditions also published in different studies.
**D** ROC curves denoting the predictive power of the same kinase activity profile correlations to discriminate between related conditions in different studies from random pairs of conditions (Mean AUC 0.933), conditions assayed in the same cell line against different (AUC = 0.546), same labelling methods versus different technique (AUC = 0.475) or samples coming from different publications with the same leading author against different leading authors (AUC = 0.499).