The NOAEL/LOAEL are then used to estimate what is referred to as acceptable daily intake of the "toxin" (ADI) or the reference dose of the toxin ("Rfd"). This is estimated as follows:
Rfd or ADI = NOAEL or LOAEL / UF1 x UF2 x ... x UFN
where UF1, UF2, ..., UFN = uncertainty factors 1 through N. The uncertainty factors themselves are estimated as follows: