Technical
-mutations must be explained in more details for non-specialists. In the discussion we learn that the 3 mutations have different “severity” (in discussion).
-If methods could be described in one or more figure, it would help a lot, especially since several lines with acronyms must be followed
-Add page and line numbers would be great to help give specific comments
-results are repeated in discussion section. Maybe a result + discussion combined section would flow better?