Acquired hemophilia A is a rare condition characterized by de novo development of a coagulation factor VIII inhibitor. Inhibition of factor VIII activity results in increased susceptibility to bleeding events, most frequently mucosal or soft tissue bleeding. We report two cases of acquired hemophilia A in previously healthy pediatric patients. Notably, both patients presented with hemarthrosis as the sentinel bleeding event. In both cases, administration of immunosuppressive therapy was associated with inhibitor loss and patient cure. These cases emphasize the importance of considering acquired hemophilia A in pediatric patients presenting with acute onset hemarthrosis.