Objective To assess the effectiveness of video-assisted childbirth education on prevention of postpartum blues among mothers. Design Quantitative quasi-experimental study using a post-test only control group design. Setting Medical College Hospital, Kottayam. Population Antenatal mothers who completed 37 weeks of gestation and were at high risk for postpartum blues. A total of 60 mothers were selected (30 control group, 30 experimental group) using non-probability purposive sampling. Methods Out of 164 mothers screened, 60 at-risk mothers were selected. The experimental group received a 45-minute video-assisted childbirth education session, while the control group received routine care. Postpartum blues was assessed on the 3rd–5th day using the modified Stein Maternity Blues Assessment Scale. Data were analyzed using descriptive and inferential statistics (Chi-square and Mann Whitney U test). Main Outcome Measures Severity of postpartum blues measured using the modified Stein Maternity Blues Assessment Scale. Results Among screened mothers, 36.4% were at risk. Mild postpartum blues was observed in 26.67% of the control group and 10% of the experimental group. A statistically significant reduction in postpartum blues was observed in the experimental group. Significant associations were found between postpartum blues and variables such as maternal age, type of family, support system, mode of delivery, gender of newborn, maternal and neonatal health status. Conclusions Video-assisted childbirth education is effective in reducing postpartum blues among at-risk mothers and can be incorporated into routine antenatal care. Funding All expenses related to the study were borne by the investigator. Keywords: Effectiveness, video assisted childbirth education, postpartum blues