Conserving tigers (Panthera tigris) in human-dominated landscapes requires careful management of human-tiger conflict. Tiger attacks on human are the extreme form of conflict occurring primarily during livelihood activities in the Terai arc landscape of Nepal. We assessed spatio-temporal patterns of tiger attacks on human and factors associated with human fatality due to attacks. We collected human tiger conflict data from the government authorities, primarily national park offices and division forest offices. We interviewed 245 victims or family members attacked by tigers between 2010 and 2024 using a semi-structured questionnaire. Most tiger attacks on human (>90%) occurred inside forest areas and over half were fatal. Men were attacked more frequently (65.3%) but fatality was higher among women (>70%). Majority of the victims (93%) were illiterate or had a low level of education and 62% were hill migrants while indigenous Terai peoples were less frequently (27%) attacked. Large number of the tiger attacks occurred during resource collection from forests or livestock herding. The victim’s group size, sex and posture during the tiger attacks affected human fatality. Tiger attack can be minimized by applying adaptive management of buffer zone and corridor forests, adopting safety protocols through behavior change campaigns, promoting alternative livelihoods and tiger tourism, and proactive management of conflict-causing tigers. The finding of this research has long term implications to strengthen human-tiger coexistence in human-dominated landscapes in Nepal and elsewhere. Keywords: Tiger attack, Human-tiger-conflict, Co-existence, Terai-arc-landscape, Nepal