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Omar  Naeim
Omar Naeim

Public Documents 1
When “Severe Asthma” Is Not Asthma: Airway-Predominant Relapsing Polychondritis as a...
Omar  Naeim
Tamer Zaalouk

Omar Naeim

and 4 more

February 06, 2026
IntroductionRelapsing polychondritis is a rare multisystem inflammatory disease characterised by episodic inflammation and progressive destruction of cartilaginous structures, most commonly affecting the ears, nose, joints, and respiratory tract. Although auricular and nasal chondritis are classically described, airway involvement is the most important determinant of prognosis and accounts for the majority of disease-related mortality [1].Respiratory involvement may precede other manifestations by several years and often presents with non-specific symptoms such as wheeze, cough, and breathlessness. As a result, airway-predominant disease is frequently misdiagnosed as asthma or chronic obstructive airway disease, leading to prolonged diagnostic delay and inappropriate escalation of asthma-directed therapies [2]. Misdiagnosis is particularly problematic when steroid dependence persists in the absence of physiological or biomarker concordance.We report a case of airway-predominant relapsing polychondritis initially treated as severe asthma, highlighting key clinical, physiological, and radiological features that may facilitate earlier recognition.

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