IntroductionSkin aging is a complex biological process influenced by intrinsic factors and extrinsic exposures such as ultraviolet radiation, environmental pollutants, and psychological stress. Clinically, aging manifests as wrinkles, dyschromia, telangiectasia, and progressive skin laxity. These changes have driven increasing demand for effective, minimally invasive rejuvenation procedures.[1]The quest for effective, minimally invasive facial rejuvenation techniques has led to the development of various laser-based treatments. The Endolift laser has emerged as a promising modality for addressing age-related skin concerns. Endolift is a minimally invasive laser procedure that targets the deep layers of the skin to stimulate collagen production, resulting in skin tightening and fat reduction. This technique involves inserting a micro-optical fiber beneath the skin, delivering laser energy directly to the subdermal layers. The thermal effect induces immediate skin contraction and promotes long-term collagen remodeling, enhancing skin elasticity and reducing sagging. We have conducted several studies evaluating the efficacy of the Endolift laser in various facial regions.[2-6] In a study focusing on treating nasolabial folds and marionette lines, the Endolift laser significantly reduced wrinkle depth and area. Biometric assessments demonstrated increased skin thickness and elasticity, with high patient satisfaction and minimal side effects.[3] Another investigation assessed the use of the Endolift laser for reducing jowl fat. The study reported significant improvements in facial contouring, with reductions in fat volume and enhanced skin tightness. Biometric measurements confirmed increased skin elasticity and thickness post-treatment, indicating the procedure’s effectiveness in lower face rejuvenation.[5] Furthermore, the application of Endolift laser for lower eye bag treatment has been explored. The results indicate a significant reduction in eye bag appearance, with increased dermal and epidermal thickness and improved skin elasticity.[3] Patients reported high satisfaction levels, and the procedure was noted for its safety and minimal downtime. These studies underscore the versatility and efficacy of the Endolift laser in facial rejuvenation, offering a non-surgical alternative for patients seeking aesthetic improvements with minimal recovery time. The procedure’s ability to enhance skin elasticity, reduce fat deposits, and improve overall facial contours makes it a valuable tool in cosmetic dermatology. In this case report, we present a 56-year-old woman who underwent a novel treatment schedule combining Platelet-Rich Fibrin (PRF) therapy with endolift laser. PRF was administered one day before, one week after, and one month after the Endolift procedure. This unique approach aimed to enhance the regenerative effects of the Endolift laser, leveraging the growth factors present in PRF to promote healing and collagen synthesis. The significant improvements observed in the patient’s facial appearance suggest a synergistic effect between PRF and Endolift, highlighting the potential for combined therapies by achieving superior aesthetic outcomes. This report contributes to the growing body of evidence supporting the use of Endolift laser in facial rejuvenation and introduces a novel treatment schedule that may optimize results. Further research is warranted to validate these findings and establish standardized protocols for combining PRF with Endolift laser in clinical practice.
